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Innovation in %Biotech often comes from pushing both science and finance into new territory. As drug developers race toward clinical trials, two levers often distinguish those that succeed: strong intellectual property protection and creative financing that sustains operations without constant dilution. These dynamics are increasingly relevant in companies combining biomedical R&D with novel treasury or asset-holding strategies—including crypto assets.

Comparables Setting the Crypto + Treasury Blueprint

%Strategy Inc. (Nasdaq: $MSTR ), formerly MicroStrategy, is perhaps the most prominent example of a corporate treasury strategy centered on %Cryptocurrency. The company has adopted Bitcoin (CRYPTO: $BTC ) as its primary treasury reserve asset. In May 2025, Strategy announced that it had raised roughly $427.0 million via ATMs (at-the-market offerings, common and preferred stock), and used those proceeds to acquire an additional 4,020 BTC, bringing its holdings to 580,250 BTC.

The strategy is transparent: raise capital with equity or preferred instruments, then convert into crypto, while also continuing its business operations in intelligence/analytics.

%BitMine Immersion Technologies (NYSE: $BMNR ) has taken a similar path, building one of the largest public company %Ethereum (CRYPTO: $ETH ) treasuries. As of mid-September 2025, BMNR holds over 2.15 million ETH plus Bitcoin and large cash reserves; total crypto + cash holdings are reported in the multi-billion-USD range (estimates vary around US$10.8 billion in recent disclosures) depending on valuations at ETH's price.

BMNR describes its strategy as a "crypto + cash + moonshots" sort of portfolio, where "moonshots" are smaller equity or token investments to capture upside beyond the core ETH / BTC holdings.

%HothTherapeutics (NASDAQ: $HOTH ), a clinical stage biotech, likewise adopted a crypto treasury reserve move in late 2024. Its board approved up to $1 million in Bitcoin as a treasury reserve asset, citing growing institutional acceptance, ETFs, and the inflation-hedge potential of cryptocurrency.

This move is more modest than Strategy or BMNR, but significant for a biotech still pre-commercial in core therapy areas; it shows that biotech companies are increasingly open to combining drug development with alternative financial hedging and treasury diversification.

Propanc Biopharma's Dual Strategy: Patents

%PropancBiopharma, Inc. (Nasdaq: $PPCB ) has taken a major step forward in its intellectual property ("IP") strategy. On September 17, 2025, Propanc received a certificate of grant from the US Patent & Trademark Office (USPTO) for its %ProenzymeComposition patent, which specifically covers a future clinical dose of its lead asset, PRP.

This is its fourth US patent granted in this jurisdiction. Propanc's total IP portfolio now comprises 90 patents filed in major jurisdictions related to the use of PRP in solid tumors.

This new patent is especially relevant as Propanc advances toward a Phase 1B, First-In-Human (FIH) study in advanced %Cancer patients. The "future clinical dose" clause protects a dosage level that Propanc anticipates using in human trials, helping secure exclusivity for a clinically meaningful formulation. The international dimension also matters: the same proenzyme composition patent has been granted in Europe, Japan, and across Southeast Asia.

Crypto and Digital Asset Diversification

Parallel to its patent progress, Propanc is also executing what it calls a digital asset diversification strategy to augment its financial flexibility, part of its plan to avoid repeated fundraising and to support operations through the pre-revenue, early clinical stage.

In early September 2025, Propanc announced its intention to acquire $100 million of Ethereum over the next 12 months. The idea is that Ethereum holdings can provide optionality: potential appreciation, liquidity, and perhaps alternative financial leverage, while not detracting from its biotech mission. The crypto asset is not the therapy; it supports the therapy financially to accelerate the drug development process and therefore the achievement of key R&D milestones.

Science and Market Potential

Propanc's therapeutic strategy is novel: PRP uses pancreatic proenzymes to target cancer stem cells and modulate EMT (epithelial-to-mesenchymal transition), encouraging malignant cells to revert to less malignant states rather than killing cells directly. This approach is designed to be relatively non-toxic, aiming to prevent metastasis and recurrence of solid %Tumors (including pancreatic, ovarian, and colorectal cancers).

The global metastatic cancer treatment market is projected to reach $111.2 billion by 2027, which gives a sense of scale should PRP enter human trials successfully.

Financing Strategy: Marrying IP, Crypto, Clinical Progress

By combining the strengthened IP portfolio with a crypto treasury strategy, Propanc is trying to create a capital structure that stretches its runway. The newly granted patents help protect future revenue / licensing potential. At the same time, the Ethereum acquisition plan could allow Propanc to raise or preserve cash without relying entirely on equity dilution or traditional biotech financings (which are costly and slow).

The plan to begin Phase 1B trials next year depends not only on the science but on having enough capital to execute. Propanc has indicated they are "pursuing every avenue for raising sufficient capital and employing a digital asset diversification strategy to ensure optimal cash flow as we advance PRP towards important clinical milestones."

Why This Matters & What to Watch

1. IP as a moat. The "clinical dose" patent makes an otherwise fuzzy area (what dose you'll use in humans) much more concrete and defensible, which can be critical in partnering/licensing or attracting big pharma.

2. Crypto asset strategy as a risk/reward lever. If Ethereum rises or remains volatile in favor, it may provide windfall or optionality.

3. Timing of Phase 1B. How quickly Propanc can move from the patent grant to human trials will be a key catalyst. The patent makes the timing more meaningful because it protects what it's going to test.

4. Comparables reinforce the model. Companies like MSTR and BMNR show that crypto-treasury strategies can attract investor attention and build valuation multiples. HOTH shows even biotech companies are starting to accept crypto reserve assets as part of treasury diversification.

Conclusion

Propanc Biopharma is threading an ambitious needle: advancing next-generation cancer treatment science (targeting cancer stem cells, EMT modulation) while simultaneously innovating with its patent protection strategy and exploring crypto asset holdings as part of its financing model. Its recent US patent grant for a clinical dose of PRP and its plan to acquire Ethereum give flesh to a "Curing Cancer Through Crypto" type rallying cry. The comparables show this path is not without precedent and where others have succeeded or drawn attention, Propanc may be next.

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